Hormones · Sleep · Longevity Rx · Prescription required

Sermorelin.

GHRH Analog

A 29-amino-acid analog of growth-hormone-releasing hormone. Stimulates the pituitary to release the body's own GH in pulses — without bypassing the natural feedback loop.

From $195 / month
MW 3357.9 Molecular weightThe mass of one molecule, in g/mol. Useful for chemistry — and a signal that this is a fully characterized molecule, not a vague extract.
Sequence 29 aa Peptide chain length29 amino acids — the bioactive N-terminal fragment of full-length GHRH (1–44). Short enough to compound cleanly, long enough to bind the GHRH receptor.
Route Sub-Q How you take itSubcutaneous: under the skin. Same technique as a GLP-1 or insulin pen, with a small insulin syringe. Most people take ~3 minutes per dose.
Cycle 3–6 mo Cycle lengthSermorelin is dosed continuously at night — typical evaluation cycle is 12 weeks. Body composition changes accumulate over months, not weeks.
Discovered 1980 First isolatedSermorelin (also called GRF 1–29) was first synthesized in the early 1980s. The full-length GHRH was characterized in 1981.
Begin your protocol Free assessment · No card · Rx required
Sermorelin Hormones
MW 3357.9 Length 29 aa Route Sub-Q Cycle 12 wk
Begin →
01 The case

The body's own GH — on a schedule.

Sermorelin is not synthetic growth hormone. It is a 29-amino-acid analog of GHRH — the upstream signal your hypothalamus already sends to your pituitary. Injected at night, it asks the pituitary to release its own GH, in its own pulses, on its own clock.

That distinction matters. Direct HGH bypasses the feedback loop entirely; the pituitary atrophies. Sermorelin works through the loop, which is why it doesn't suppress endogenous production and why dosing is sustainable for months.

What members notice first is sleep — deeper, more restorative, fewer wake-ups. Body composition follows over weeks. Cognitive clarity is downstream of both.

02 Mechanism

Where it acts.

Six effects flow from one upstream binding event — the GHRH receptor on pituitary somatotrophs.

Sermorelin C₁₄₉H₂₄₆N₄₄O₄₂S
⌬ GHRH receptor Selective binding on pituitary somatotrophs
∿ Pulsatile GH Releases GH in physiologic pulses, not floods
↗ IGF-1 elevation Downstream hepatic IGF-1 follows GH pulses
◐ Slow-wave sleep Deeper N3 — the GH-releasing window
⊖ Lipolysis Mobilization of stored adipose, especially visceral
⌒ Lean synthesis Anabolic environment for muscle and bone
03 Evidence

Forty years of endocrinology.

Sermorelin was approved in 1997 (Geref) for pediatric GH deficiency. Adult use is off-label but built on decades of mechanism studies.

50%

decline in endogenous GH between ages 20 and 50

Savine & Sonksen · 2000
3 mo

typical body-composition improvements at recommended dose

Walker · 1990
29 aa

bioactive fragment of full-length GHRH (1–44)

Endocrine literature
0

pituitary suppression — preserves the natural feedback loop

Mechanism review
04 Who it's for

Built for the GH axis.

Most commonly prescribed for adults noticing GH-axis decline — the sleep, body composition, and recovery cluster.

◐

Sleep depth

Deeper N3, fewer wakings — the most-reported early effect.

⌒

Lean mass

Anabolic signal for muscle protein synthesis.

⊖

Fat loss

Mobilization of visceral and stubborn adipose.

⚛

Skin & collagen

Improved elasticity and dermal thickness over months.

∿

Cognitive clarity

Downstream of better sleep and IGF-1 normalization.

↗

Bone density

GH-axis support for skeletal maintenance.

05 Protocol

A sample protocol.

The parameters below are illustrative. Your dose and timing are written by a U.S.-licensed physician based on your bloodwork and goals.

Sample parameters

Illustrative
Route
Subcutaneous injection
Dose
200–300 mcg
Frequency
Nightly (before bed)
Cycle
3–6 months
Storage
Refrigerated, light-protected

Take it at night. Sermorelin is dosed before bed to ride the natural GH pulse during slow-wave sleep. Compounded fresh by a 503A pharmacy to USP 797 sterile standards.

The cadence

Your week 7 days · nightly
MPM
TPM
WPM
TPM
FPM
SPM
SPM
Your cycle 12 wk · continuous
1on
2on
3on
4on
5on
6on
7on
8on
~3 min per dose Site rotates: abdomen · thigh
06 What arrives

In the box.

Compounded fresh, cold-chain shipped overnight from a U.S.-based 503A pharmacy. Everything you need to start the same week.

⚲
Compounded vials

Multi-dose vial · USP 797 sterile · beyond-use date printed.

⊕
Injection supplies

Insulin syringes, alcohol pads, bacteriostatic water for reconstitution.

❄
Cold-pack shipping

Insulated overnight delivery with ice pack. Tracked door to door.

📖
Step-by-step guide

Reconstitution, dosing math, injection technique, sharps disposal.

07 Often paired with

Stacks that work.

Sermorelin is most often paired with stacks that reinforce the GH axis or compound its anabolic environment.

CJC-1295 + Ipa

Pairs with Sermorelin's GHRH activity for stronger, longer GH pulses — the most common GH stack.

Synergy stackFrom $250/mo →
BPC-157

BPC-157's local repair benefits from the anabolic environment Sermorelin creates.

Recovery + GHFrom $225/mo →
08 Safety

Side effects, fine print, responsibility.

Sermorelin is generally well-tolerated. Here's what to expect and where it isn't appropriate.

✓

What to expect

  • 01Mild injection-site reactions — redness, light bruising. The most common report.
  • 02Occasional flushing or warmth — transient, usually only in the first week of dosing.
  • 03No HPA suppression — preserves natural GHRH feedback — distinct from synthetic HGH.
  • 04Effects within 4–8 weeks — sleep changes earlier; body composition over months.
!

Not for

  • 01Pregnancy or breastfeeding. Insufficient safety data.
  • 02Active malignancy. GH axis stimulation is not appropriate during cancer treatment.
  • 03Use without oversight. Always under a licensed physician's supervision.
  • 04Known peptide allergy. Disclose any prior peptide-class reactions during intake.

Compounded Sermorelin is dispensed by prescription only. Sermorelin is the active ingredient in the FDA-approved drug Geref (since discontinued in the U.S.). Compounded versions are dispensed by licensed 503A pharmacies under a prescription written by a U.S.-licensed physician for individual use. Statements on this page have not been evaluated by the FDA. Individual results vary.

09 Questions

Frequently asked.

What is Sermorelin?+

Sermorelin is a 29-amino-acid analog of growth-hormone-releasing hormone (GHRH). It binds the GHRH receptor on pituitary somatotrophs, asking the pituitary to release its own GH in physiologic pulses — without bypassing the natural feedback loop.

How is it different from HGH?+

Synthetic HGH replaces the hormone directly and suppresses endogenous production over time. Sermorelin works upstream — it asks the pituitary to do its job. The result is closer to physiology, with a much cleaner safety profile.

When do I inject it?+

At night, usually 30–60 minutes before bed, on an empty stomach. The timing rides the natural GH pulse that occurs during slow-wave sleep.

How long until I see results?+

Sleep depth often shifts within the first 2–4 weeks. Body composition and skin/collagen changes typically emerge over 8–12 weeks. Full benefits accrue across multiple cycles.

Can I stack it with other peptides?+

Yes — Sermorelin is commonly stacked with CJC-1295 + Ipamorelin for stronger GH pulses, with BPC-157 for recovery, or with Glutathione as a foundational antioxidant. Your physician designs the stack based on your goals.

What are the side effects?+

Generally well tolerated. Most common: mild injection-site redness, occasional warmth or flushing in the first week. No HPA suppression. Disclose any prior peptide-class reactions during intake.

Begin Ten minutes of intake

Begin your Sermorelin protocol.

Free assessment. A board-certified U.S. physician on the prescription. Bloodwork only if your protocol calls for it. Compounded fresh and cold-chain shipped overnight.

Start your intake Free · No card required · Rx required to ship

Other compounds in the roster.

All 8 therapies →
BPC-157

15-aa fragment from gastric juice. Tendon, ligament, gut. The repair signal stack-mate.

From $225/mo CJC-1295 + Ipa

Long-acting GHRH paired with a selective GH secretagogue. Stronger pulse, no cortisol spike.

From $250/mo

Deeper guides on Sermorelin.

All guides →