Hormones · Sleep · Body composition · Longevity Rx · Prescription required

CJC-1295 + Ipamorelin.

Long-acting GHRH + selective GH secretagogue

A long-acting GHRH paired with a third-generation selective GH secretagogue. Stronger, cleaner pulses than either alone — without the cortisol or hunger spikes of older peptides.

From $250 / month

MW 3367.2 + 711.9

Sequence 30 aa + 5 aa

Route Sub-Q

Cycle 3–6 mo

Discovered 1998 / 2005

Begin your protocol Free assessment · No card · Rx required

CJC-1295 + Ipamorelin Hormones

MW 3367.2 + 711.9 Length 30 aa + 5 aa Route Sub-Q Cycle 12 wk

Begin →

01 The case

Two signals, one pulse.

The CJC + Ipa stack works because GH release is governed by two upstream switches — GHRH and ghrelin. CJC-1295 sustains the GHRH signal through the night; Ipamorelin pulls on the ghrelin lever in parallel. Together they produce a larger, cleaner GH pulse than either does alone.

What sets this combo apart from older GH secretagogues is what it doesn't do. No cortisol spike. No prolactin elevation. No hunger crisis. Ipamorelin is the most selective GH secretagogue published — that selectivity is the entire point.

For members building lean mass, recovering from training loads, or trying to compress recovery between sessions, this is the GH stack physicians reach for first.

02 Mechanism

Two switches, one outcome.

GH release is dual-gated. Pulling both gates at once — the way the body itself does — is the cleanest way to amplify the pulse.

CJC + Ipa GHRH + GHRP

⌬ Sustained GHRH CJC-1295 with DAC has a multi-day half-life

∿ Selective secretagogue Ipamorelin pulls the ghrelin lever cleanly

⊖ No cortisol Unlike GHRP-6 / hexarelin, no HPA activation

◐ No hunger Selective for GH — does not engage appetite circuits

↗ Pulse synergy Combined pulse 2–3× larger than either alone

⌒ IGF-1 elevation Downstream hepatic IGF-1 with a clean profile

03 Evidence

Selectivity is the innovation.

Older GH secretagogues (GHRP-6, hexarelin) worked but came with cortisol and prolactin spikes. Ipamorelin's selectivity changed the field.

2-3×

greater GH pulse vs Sermorelin alone in published comparison

Raun et al · 1998

Days

CJC-1295 half-life vs minutes for natural GHRH (with DAC)

Ionescu · 2006

cortisol or prolactin spike — the cleanest GH secretagogue

Raun et al · 1998

8 wk

typical timeline to visible lean composition change

Clinical observation

04 Who it's for

Built for the GH stack.

When the goal is lean mass, recovery, or sleep, the CJC + Ipa stack is the GH-axis tool most physicians reach for.

⌒

Lean muscle

Strong anabolic signal for muscle protein synthesis.

⊖

Fat loss

GH-driven lipolysis, especially visceral.

↗

Recovery

Faster turnaround between hard sessions.

◐

Sleep

Deeper N3 alongside larger nocturnal GH pulse.

⚛

Anti-aging

Skin, collagen, dermal thickness over months.

∿

No-cortisol GH

Cleanest GH boost in the secretagogue class.

05 Protocol

A sample protocol.

The parameters below are illustrative. Your physician sets the actual dose and timing based on your bloodwork and goals.

Sample parameters

Illustrative

Route: Subcutaneous injection
Dose: 300 mcg CJC + 300 mcg Ipa
Frequency: 5 days on / 2 off
Cycle: 3–6 months
Storage: Refrigerated, light-protected

Combined in one syringe. Both peptides are stable when reconstituted together and dosed before bed. Compounded fresh by a 503A pharmacy to USP 797 sterile standards.

The cadence

Your week 7 days · nightly

MPM

TPM

WPM

TPM

FPM

SPM

Your cycle 12 wk · continuous

1on

2on

3on

4on

5on

6on

7on

8on

~3 min per dose Combined in one syringe

06 What arrives

In the box.

Compounded fresh, cold-chain shipped overnight from a U.S.-based 503A pharmacy. Everything you need to start the same week.

⚲

Compounded vials

Multi-dose vial · USP 797 sterile · beyond-use date printed.

⊕

Injection supplies

Insulin syringes, alcohol pads, bacteriostatic water for reconstitution.

❄

Cold-pack shipping

Insulated overnight delivery with ice pack. Tracked door to door.

📖

Step-by-step guide

Reconstitution, dosing math, injection technique, sharps disposal.

07 Often paired with

Stacks that work.

Most often paired with foundational stacks that complement the GH-axis amplification.

BPC-157

Local repair complements the systemic anabolic environment CJC + Ipa creates.

RecoveryFrom $225/mo →

NAD+

Cellular energy substrate amplifies what the GH-axis is asking the body to do.

LongevityFrom $200/mo →

08 Safety

Side effects, fine print, responsibility.

The cleanest GH stack in the published literature, but not free of effects. Here's what to expect.

✓

What to expect

01Mild injection-site reactions — redness, light bruising. The most common report.
02Brief flushing or warmth — transient, usually limited to the first week.
03No cortisol or hunger spike — the defining feature vs older GH secretagogues.
04Composition shifts in 8–12 wk — lean mass and visceral fat changes accumulate.

Not for

01Pregnancy or breastfeeding. Insufficient safety data.
02Active malignancy. GH axis stimulation is not appropriate during cancer treatment.
03Active retinopathy. GH/IGF-1 elevation can complicate proliferative disease.
04Use without oversight. Always under a licensed physician's supervision.

Compounded CJC-1295 + Ipamorelin are not FDA-approved drug products. Both ingredients are dispensed by licensed 503A compounding pharmacies under a prescription written by a U.S.-licensed physician for individual investigational and off-label use under provider supervision. Statements on this page have not been evaluated by the FDA. Individual results vary.

09 Questions

Frequently asked.

What is the CJC + Ipa stack?+

It's two peptides dosed together. CJC-1295 is a long-acting GHRH analog (the 'sustained' signal), Ipamorelin is a selective ghrelin-receptor agonist (the 'pulse' signal). Together they produce a larger, cleaner GH release than either does alone.

Why combine them?+

GH release is governed by two upstream switches — GHRH and ghrelin. Pulling both at once amplifies the pulse without the cortisol or hunger spikes of older single-mechanism peptides.

How is this different from Sermorelin?+

Sermorelin only pulls the GHRH lever and lasts a few minutes per dose. CJC + Ipa pulls both levers, with a multi-day half-life on the GHRH side. Result: stronger pulses, fewer doses to the same endpoint.

When do I inject?+

At night, usually 30–60 minutes before bed, on an empty stomach. Some protocols split into AM and PM doses; your physician decides.

Will it spike my cortisol or appetite?+

No. Ipamorelin's selectivity is its defining feature — it does not activate cortisol, prolactin, or hunger circuits. That's the entire reason the stack exists.

How long is a typical cycle?+

12 weeks continuous is the standard evaluation cycle. Body composition changes accrue over multiple cycles. Your physician will reassess at the end of each.

Begin Ten minutes of intake

Begin your CJC + Ipa protocol.

Free assessment. A board-certified U.S. physician on the prescription. Bloodwork only if your protocol calls for it. Compounded fresh and cold-chain shipped overnight.

Start your intake Free · No card required · Rx required to ship